Drug Standards
Apexbio Technology LLC ANTI-PD-1 NIVOLUMAB-5mg
Anti-PDCD1/PD-1/CD279 Antibody (Nivolumab) (CAS No 946414-94-4) is a monoclonal antibody widely studied in immunotherapy research originating from humanized antibodies It targets the PD-1 pathway an immune checkpoint that when inhibited can enhance the body s immune response against various cancer cells This antibody functions by blocking the interaction between PD-1 and its ligands PD-L1 and PD-L2 thus restoring the function of T-cells in the tumor microenvironment Common in vitro activity is observed in the nanomolar to low micromolar range It is typically used in cellular assays animal models and drug screening to assess immune response modulation and tumor inhibition Experimental concentrations typically depend on the specific research design
Medchemexpress LLC Tenofovir exalidex | 911208-73-6 | MFCD23843795 | 99.8% | 569.7 g/mol | C28H52N5O5P | 5 MG
Tenofovir exalidex is a lipid-conjugated prodrug of the nucleotide analog tenofovir supplied as a research and analytical standard. It exhibits potent antiviral activity against wild-type and drug-resistant HIV strains and shows activity against hepatitis B virus, and is provided in small milligram quantities for in vitro and analytical applications.
- Lipid-conjugated prodrug designed for improved cell delivery and oral availability.
- Potent activity against wild-type and antiretroviral-resistant HIV strains.
- Demonstrates antiviral activity against hepatitis B virus (HBV).
- Provided as a high-purity analytical standard suitable for in vitro assays.
- Available in small milligram package sizes for research and assay development.
Cayman Chemical ImatInIb-d3 500ug
An internal standard for the quantification of imatinib by GC- or LC-MS
Apexbio Technology LLC (-)-epicatechin gallate 1257-08-5 10mM (in 1mL DMSO)
(-)-Epicatechin gallate (ECG) is a catechin compound abundant in green tea displaying bioactivity to modulate cell proliferation apoptosis and gene expression pathways In colon HCT-116 cells ECG induces apoptosis through activating transcription factor 3 (ATF3) regulated via activation of early growth response protein 1 (EGR-1) In these cancer cells ECG upregulates apoptotic factor NAG-1 and increases caspase-3 activity at concentrations around 150 M ECG s cytotoxic potency differs among cell types with an NR50 (midpoint cytotoxic concentration) of approximately 67 M in HSC-2 oral cancer cells while normal human fibroblast HGF-2 cells show greater resistance with an NR50 near 100 M ECG metabolites identified in rat urine include various O-methylated derivatives useful as biomarkers for metabolism studies ECG serves as a research tool for oncology mechanisms and apoptosis signaling pathways
Medchemexpress LLC Metformin-d6 hydrochloride | 1185166-01-1 | MFCD06658649 | 98.0% | 171.66 g/mol | C4H6D6ClN5 | 5 MG
Metformin-d6 hydrochloride is a deuterium-labeled metformin hydrochloride supplied as a research-grade analytical standard for use as an internal standard in quantitative LC-MS/GC-MS and tracer studies. For laboratory research use only; not for human consumption.
- Deuterium-labeled analogue suitable as an internal standard for mass spectrometry.
- High chemical purity: 98.0% as reported by supplier certificate of analysis.
- High isotopic enrichment (99.8%), supporting accurate quantification and tracing.
- Available as a solid in small analytical quantities for method development and validation.
- Compatible with common analytical workflows including LC-MS and GC-MS.
Medchemexpress LLC Methylprednisolone succinate | 2921-57-5 | 99.7% | 1 ML
Methylprednisolone succinate is a prodrug of Methylprednisolone and a glucocorticoid with immunosuppressant and anti-inflammatory activity. It functions by binding to cytosolic glucocorticoid receptors, modulating target gene transcription, and suppressing proinflammatory cytokine production and immune cell activation. This compound is researched for various conditions, including intracranial hemorrhage, rheumatoid arthritis, multiple sclerosis, and inflammatory states.
- Prodrug of Methylprednisolone.
- Possesses immunosuppressant and anti-inflammatory properties.
- Modulates target gene transcription.
- Suppresses proinflammatory cytokine production.
- Attenuates TLR4/NF-κB signaling.
- Researched for intracranial hemorrhage, rheumatoid arthritis, and multiple sclerosis.
- Available as a 10 mM solution in DMSO.
Medchemexpress LLC Doxycycline | 564-25-0 | MFCD00800994 | 444.4 g/mol | 100 MG
Doxycycline is a semi-synthetic tetracycline antibiotic that functions by inhibiting bacterial protein synthesis. It is widely used to treat various bacterial infections and also exhibits geroprotector, antimalarial, immunomodulatory, and anti-inflammatory properties.
- Inhibits bacterial protein synthesis
- Treats bacterial infections
- Acts as a geroprotector
- Possesses antimalarial properties
- Functions as an immunomodulator
- Exhibits anti-inflammatory effects
Sigma Aldrich Fine Chemicals Biosciences Pyrrolidone European Pharm
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
Sigma Aldrich Fine Chemicals Biosciences Fenbendazole Related Compound B United States Pharmacopeia (USP) Reference Standard | 20367-38-8 | 30MG
Fenbendazole Related Compound B United States Pharmacopeia (USP) Reference Standard | Mol Wt: 225.63 | 20367-38-8 | 30MG
Medchemexpress LLC Colchicine | 64-86-8 | 99.9% | 399.44 | 100 MG
Colchicine is an orally active alkaloid that acts as a potent tubulin inhibitor and a microtubule disrupting agent. It is intended for research and analytical applications.
- Inhibits microtubule polymerization with an IC50 of 3 nM.
- Acts as a competitive antagonist of the α3 glycine receptors (GlyRs).
- Prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome.
- Possesses extensive anti-inflammatory, immunosuppressive, and strong anti-fibrosis effects.
- Has potential for gouty arthritis research.
- Commonly used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Can be used to induce Alzheimer's disease models.
Sigma Aldrich Fine Chemicals Biosciences Felodipine United States Pharmacopeia (USP) Reference Standard | 72509-76-3 | MFCD00868316 | 300MG
Felodipine United States Pharmacopeia (USP) Reference Standard | Mol Wt: 384.25 | 72509-76-3 | MFCD00868316 | 300MG
AdipoGen Rosiglitazone, 122320-73-4, MFCD00871760, 10 mg
MF: C18H19N3O3S, MW: 357.4, ≥98%, Appearance: White to off-white powder. Antidiabetic, hypoglycemic agent. Potent and selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance. Improves blood pressure and vascular function. Enhances proliferation of endogenous neural progenitor cells (NPCs). Anti-inflammatory compound. Has controversial therapeutic effects on the cardiovascular system. Promotes adipocyte differentiation of mesenchymal stem cells (MSCs).